New (3-lactam Antibiotics, Carpetimycins C and D
نویسندگان
چکیده
Two new carbapenem antibiotics, carpetimycins C and D have been isolated from the culture broth of Streptomyces p. KC-6643, which produced carpetimycins A and B. The structures of carpetimycins C and D have been determined to be (5R,6R)-3-[2-acetamidoethyl(R)-sulfinyl]-6-(1-hydroxy-l-methylethyl)-7-oxo-l-azabicyclo[3.2.0]hept-2-ene-2-carboxylic a id and (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]-6-(1-hydroxysulfonyloxy-l-methylethyl)-7-oxo-1azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, respectively. Studies on the fermentation, isolation and physico-chemical properties of these antibiotics are also described.
منابع مشابه
Structures and absolute configurations of carpetimycins A and B.
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